Blar i NILU Brage på forfatter "Pfuhler, Stefan"
-
Common Considerations for Genotoxicity Assessment of Nanomaterials
Elespuru, Rosalie K.; Doak, Shareen H.; Collins, Andrew Richard; Dusinska, Maria; Pfuhler, Stefan; Manjanatha, Mugamane; Cardoso, Renato M.S.; Chen, Connie L. (Peer reviewed; Journal article, 2022)Genotoxicity testing is performed to determine potential hazard of a chemical or agent for direct or indirect DNA interaction. Testing may be a surrogate for assessment of heritable genetic risk or carcinogenic risk. Testing ... -
In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Cardoso, Renato; Dusinska, Maria; Collins, Andrew Richard; Manjanatha, Mugamane; Pfuhler, Stefan; Registre, Marilyn; Elespuru, Rosalie K. (Peer reviewed; Journal article, 2022)The in vivo Comet assay measures the generation of DNA strand breaks under conditions in which the DNA will unwind and migrate to the anode in an electrophoresis assay, producing comet-like figures. Measurements are on ... -
Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT)
Pfuhler, Stefan; van Benthem, Jan; Curren, Rodger; Doak, Shareen H.; Dusinska, Maria; Hayashi, Makoto; Heflich, Robert H.; Kidd, Darren; Kirkland, David; Luan, Yang; Ouedraogo, Gladys; Reisinger, Kerstin; Sofuni, Toshio; van Acker, Frederique; Yang, Ying; Corvi, Raffaella (Peer reviewed; Journal article, 2020)Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress ...